Presumptive treatment with sulphadoxine-pyrimethamine versus weekly chloroquine for malaria prophylaxis in children with sickle cell anaemia in Uganda: a randomized controlled trial
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منابع مشابه
Effect of Lisinopril on Microalbuminuria in Sickle Cell Anaemia Children: A Single-Blind Randomized Controlled Trial
Background Sickle cell nephropathy is a major cause of morbidity and mortality in sickle cell anaemia (SCA). Proteinuria contributes to progression of renal damage. Icroalbuminuria is an early feature of SCN and progression to advanced kidney damage is delayed if regression is achieved with angiotensin converting enzyme inhibitors. We aimed to ...
متن کاملA randomized comparison of sulphadoxine-pyrimethamine and combination of sulphadoxine pyrimethamine with chloroquine in the treatment of uncomplicated falciparum malaria in Eastern Sudan.
arly diagnosis and effective treatment with appropriate drug is the main component of the World Health Organization (WHO) strategy to reduce malaria-related mortality.1 For many years the treatment of malaria in Africa has relied on chloroquine, sulphadoxine-pyrimethamine (SP), and quinine, with the latter being used mainly to treat severe cases. Chloroquine and SP are failing and leading to an...
متن کاملIntermittent preventive treatment with sulfadoxine-pyrimethamine versus weekly chloroquine prophylaxis for malaria in pregnancy in Honiara, Solomon Islands: a randomised trial
1 National Vector Borne Disease Control Division, Ministry of Health and Medical Services, Solomon Islands 2 Queensland Institute of Medical Research, University of Queensland, Brisbane, Australia 3 Reproductive and Child Health Division, Ministry of Health and Medical Services, Solomon Islands 4 Division of Health Promotion, Ministry of Health and Medical Services, Solomon Islands 5 Department...
متن کاملChloroquine/Sulphadoxine-Pyrimethamine for Gambian Children with Malaria: Transmission to Mosquitoes of Multidrug-Resistant Plasmodium falciparum
OBJECTIVES In the Gambia, chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) is the first-line antimalarial treatment. Plasmodium falciparum parasites carrying mutations associated with resistance to each of these drugs were present in 2001 but did not cause a significant loss of therapeutic efficacy among children receiving the combination CQ/SP. We measured their effect on parasite transmi...
متن کاملRandomised Trial of Chloroquine/Sulphadoxine-Pyrimethamine in Gambian Children with Malaria: Impact against Multidrug-Resistant P. falciparum
OBJECTIVES In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence of parasites carrying alleles associated with resistance to CQ or SP. DESIGN We conducted a single-blind, randomised, controlled trial to com...
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ژورنال
عنوان ژورنال: Malaria Journal
سال: 2009
ISSN: 1475-2875
DOI: 10.1186/1475-2875-8-237